April 22 - Treaty of Saragossa divides the eastern hemisphere between Spain and Portugal, stipulating that the dividing line should lie 297.5 leagues or 17° east of the Moluccas.
March 7 or 9 - At the Battle of Shimbra Kure, Imam Ahmad ibn Ibrihim al-Ghazi, with 200 men armed with matchlocks, defeats the army of Lebna Dengel, Emperor of Ethiopia.
October 15 - With the season growing late, Suleiman abandons the siege.
Emperor Charles V and Francis I of France sign the Treaty of Cambrai, or the "Ladies' Peace". Francis abandons his claims in Italy, but is allowed to retain Burgundy.
Thomas Wolsey, Archbishop of York, fails to bring about the divorce and annulment Henry VIII had sought and is forced to resign.